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The following is a list of some of the most recent publications from our faculty. For a complete list of publications of individual faculty members go to faculty and click on the name to get to the personal webpages.


Maureen Ajuebor

Ajuebor MN, Chen Q, Strieter RM, Adegboyega PA, Aw TY.
V{alpha}14iNKT cells Promote Liver Pathology during Adenovirus Infection by Inducing CCL5 Production: Implications for Gene Therapy.
J Virol. 2010 Jun 23. [Epub ahead of print]

pdf-fileabstract
   

Ajuebor MN, Jin Y, Gremillion GL, Strieter RM, Chen Q, Adegboyega PA.

GammadeltaT cells initiate acute inflammation and injury in adenovirus-infected liver via cytokine-chemokine cross talk.
J Virol. 2008 Oct;82(19):9564-76. Epub 2008 Jul 30.

abstractpdf-file

 

Jonathan Steven Alexander
Yilmaz G, Alexander JS, Erkuran Yilmaz C, Granger DN.
Induction of neuro-protective/regenerative genes in stem cells infiltrating post-ischemic brain tissue.
Exp Transl Stroke Med. 2010 May 28;2(1):11.
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Minagar A, Alexander JS, Sahraian MA, Zivadinov R.
Alemtuzumab and multiple sclerosis: therapeutic application.
Expert Opin Biol Ther. 2010 Mar;10(3):421-9. Review.

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Alexander JS, Ganta VC, Jordan PA, Witte MH.

Gastrointestinal lymphatics in health and disease.
Pathophysiology. 2009 Dec 16. [Epub ahead of print]

abstract
 

Alexander JS.

Editorial: Lymphatic vessel functions in Health and Disease.
Pathophysiology. [Epub ahead of print] No abstract available.

abstract

 

Tak Yee Aw

Okouchi M, Okayama N, Aw TY.

Preservation of cellular glutathione status and mitochondrial membrane potential by N-acetylcysteine and insulin sensitizers prevent carbonyl stress-induced human brain endothelial cell apoptosis.
Curr Neurovasc Res. 2009 Nov;6(4):267-78.

abstract
   

Li TW, Zhang Q, Oh P, Xia M, Chen H, Bemanian S, Lastra N, Circ M, Moyer MP, Mato JM, Aw TY, Lu SC.

S-Adenosylmethionine and methylthioadenosine inhibit cellular FLICE inhibitory protein expression and induce apoptosis in colon cancer cells.
Mol Pharmacol. 2009 Jul;76(1):192-200. Epub 2009 Apr 16.

abstract
   

Li TW, Zhang Q, Oh P, Xia M, Chen H, Bemanian S, Lastra N, Circ M, Moyer MP, Mato JM, Aw TY, Lu SC.

S-Adenosylmethionine and Methylthioadenosine Inhibit Cellular FLICE Inhibitory Protein Expression and Induce Apoptosis in Colon Cancer Cells.

Mol Pharmacol. 2009 Apr 16. [Epub ahead of print]

pdf-fileabstract

 

Magda Circu

Circu ML, Aw TY.

Reactive oxygen species, cellular redox systems, and apoptosis.
Free Radic Biol Med. 2010 Jan 4. [Epub ahead of print]

   

Circu ML, Moyer MP, Harrison L, Aw TY.

Contribution of glutathione status to oxidant-induced mitochondrial DNA damage in colonic epithelial cells.
Free Radic Biol Med. 2009 Oct 15;47(8):1190-8. Epub 2009 Aug 6.

   

Circu ML, Stringer S, Rhoads CA, Moyer MP, Aw TY.

The role of GSH efflux in staurosporine-induced apoptosis in colonic epithelial cells.
Biochem Pharmacol. 2009 Jan 1;77(1):76-85. Epub 2008 Sep 17.

abstractpdf-file

 

D. Neil Granger

Granger DN, Rodrigues SF, Yildirim A, Senchenkova EY.
Microvascular responses to cardiovascular risk factors.
Microcirculation. 2010 Apr;17(3):192-205. Review.

   

Rodrigues SF, Granger DN.
Role of blood cells in ischaemia-reperfusion induced endothelial barrier failure.
Cardiovasc Res. 2010 Jul 15;87(2):291-9. Epub 2010 Mar 17.

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Nagai M, Yilmaz CE, Kirchhofer D, Esmon CT, Mackman N, Granger DN.
Role of coagulation factors in cerebral venous sinus and cerebral microvascular thrombosis.
Neurosurgery. 2010 Mar;66(3):560-5; discussion 565-6.

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Saijo F, Milsom AB, Bryan NS, Bauer SM, Vowinkel T, Ivanovic M, Andry C, Granger DN, Rodriguez J, Feelisch M.

On the dynamics of nitrite, nitrate and other biomarkers of nitric oxide production in inflammatory bowel disease.
Nitric Oxide. 2009 Dec 11. [Epub ahead of print]

abstract
 

Nagai M, Terao S, Yilmaz G, Yilmaz CE, Esmon CT, Watanabe E, Granger DN.

Roles of inflammation and the activated protein C pathway in the brain edema associated with cerebral venous sinus thrombosis.
Stroke. 2010 Jan;41(1):147-52. Epub 2009 Nov 5.

abstract

 

Matthew Grisham

Abe Y, Urakami H, Ostanin D, Zibari G, Hayashida T, Kitagawa Y, Grisham MB.

Induction of Foxp3-expressing regulatory T-cells by donor blood transfusion is required for tolerance to rat liver allografts.
PLoS One. 2009 Nov 23;4(11):e7840.

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Cornelius J, Tran T, Turner N, Piazza A, Mills L, Slack R, Hauser S, Alexander JS, Grisham MB, Feelisch M, Rodriguez J.

Isotope tracing enhancement of chemiluminescence assays for nitric oxide research.
Biol Chem. 2009 Feb;390(2):181-9

abstract
   

Ostanin DV, Boa R, Koboziev I, Gray L, Robinson-Jackson SA, Kosloski-Davidson M, Price VH, Grisham MB.

T-Cell Transfer Model of Chronic Colitis: Concepts, Considerations and Tricks of the Trade.
Am J Physiol Gastrointest Liver Physiol. 2009 Feb;296(2):G135-46. Epub 2008 Nov 25.

abstractpdf-file
   

Abe Y, Hines IN, Zibari G, Pavlick K, Gray L, Kitagawa Y, Grisham MB.

Mouse model of liver ischemia and reperfusion injury: method for studying reactive oxygen and nitrogen metabolites in vivo.
Free Radic Biol Med. 2009 Jan 1;46(1):1-7.  Epub 2008 Oct 10.

abstractpdf-file

 

Norman R. Harris  

Wright WS, McElhatten RM, Messina JE, Harris NR.

Hypoxia and the expression of HIF-1alpha and HIF-2alpha in the retina of streptozotocin-injected mice and rats.
Exp Eye Res. 2009 Dec 11. [Epub ahead of print]

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Harris NR, Carter PR, Lee S, Watts MN, Zhang S, Grisham MB.

Association between blood flow and inflammatory state in a T-cell transfer model of inflammatory bowel disease in mice.
Inflamm Bowel Dis. 2009 Oct 9. [Epub ahead of print]

pdf-fileabstract
   

Wright WS, McElhatten RM, Harris NR.

Expression of thromboxane synthase and the thromboxane-prostanoid receptor in the mouse and rat retina.

Exp Eye Res. 2009 Oct;89(4):532-7. Epub 2009 Jun 11.

abstract
   

Harris NR, Whatley JR, Carter PR, Morgan GA, Grisham MB.

Altered microvascular hemodynamics during the induction and perpetuation of chronic gut inflammation.

Am J Physiol Gastrointest Liver Physiol. 2009 Apr;296(4):G750-4. Epub 2009 Feb 12.

abstract
   

Wright WS, Messina JE, Harris NR.

Attenuation of diabetes-induced retinal vasoconstriction by a thromboxane receptor antagonist.
Exp Eye Res. 2008 Nov 1. [Epub ahead of print]

pdf-fileabstract

 

Lynn Harrison

Malyarchuk S, Castore R, Harrison L.

Apex1 can cleave complex clustered DNA lesions in cells.
DNA Repair (Amst). 2009 Dec 3;8(12):1343-54. Epub 2009 Oct 1.

 

Malyarchuk S, Castore R, Harrison L.

DNA repair of clustered lesions in mammalian cells: involvement of non-homologous end-joining.
Nucleic Acids Res. 2008 Sep;36(15):4872-82. Epub 2008 Jul 24.

abstract

 

Yijun Jin

Gardner TR, Chen Q, Jin Y, Ajuebor MN.
Toll-like receptor 3 ligand dampens liver inflammation by stimulating Valpha 14 invariant natural killer T cells to negatively regulate gammadeltaT cells.
Am J Pathol. 2010 Apr;176(4):1779-89. Epub 2010 Feb 18.

 
   

Gardner T, Chen Q, Jin Y, Ajuebor MN.

Characterization of the role of TCRgammadelta in NK cell accumulation during viral liver inflammation.
Exp Mol Pathol. 2009 Feb;86(1):32-5.  Epub 2008 Nov. 6

abstractpdf-file

 

Kevin Pruitt

Holloway KR, Calhoun TN, Saxena M, Metoyer CF, Kandler EF, Rivera CA, Pruitt K.
SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling.
Proc Natl Acad Sci U S A. 2010 May 18;107(20):9216-21. Epub 2010 May 3.

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Metoyer CF, Pruitt K.

The role of sirtuin proteins in obesity.
Pathophysiology. 2008 Aug;15(2):103-8. Epub 2008 Jul 2.

abstract
   

Ohm JE, McGarvey KM, Yu X, Cheng L, Schuebel KE, Cope L, Mohammad HP, Chen W, Daniel VC, Yu W, Berman DM, Jenuwein T, Pruitt K, Sharkis SJ, Watkins DN, Herman JG, Baylin SB.

A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet. 2007 Feb;39(2):237-42. Epub 2007 Jan 9.

 

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Chantal Rivera

Rivera CA, Gaskin L, Allman M, Pang J, Brady K, Adegboyega P, Pruitt K.
Toll-like receptor-2 deficiency enhances non-alcoholic steatohepatitis.
BMC Gastroenterol. 2010 May 28;10:52.

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Allman M, Gaskin L, Rivera CA.
CCl4-induced hepatic injury in mice fed a Western diet is associated with blunted healing.
J Gastroenterol Hepatol. 2010 Mar;25(3):635-43.

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Xu F, Gao Z, Zhang J, Rivera CA, Yin J, Weng J, Ye J.
Lack of SIRT1 (Mammalian Sirtuin 1) activity leads to liver steatosis in the SIRT1+/- mice: a role of lipid mobilization and inflammation.
Endocrinology. 2010 Jun;151(6):2504-14. Epub 2010 Mar 25.

abstract

 

Robert Specian

Harris NR, Specian RD, Carter PR, Morgan GA.

Contrasting effects of pseudoephedrine and papaverine in dextran sodium sulfate-induced colitis.

Inflamm Bowel Dis. 2008 Mar;14(3):318-23.

abstractpdf-file
   

Tailor A, Wood KC, Wallace JL, Specian RD, Granger DN.

Roles of platelet and endothelial cell COX-1 in hypercholesterolemia-induced microvascular dysfunction.
Am J Physiol Heart Circ Physiol. 2007 Dec;293(6):H3636-42. Epub 2007 Oct 12.

abstractpdf-file

 

Karen Stokes

Jiang B, Hebert VY, Khandelwal AR, Stokes KY, Dugas TR.

HIV-1 antiretrovirals induce oxidant injury and increase intima-media thickness in an atherogenic mouse model.

Toxicol Lett. 2009 Jun 22;187(3):164-71. Epub 2009 Mar 9.

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Stokes KY, Dugas TR, Tang Y, Garg H, Guidry E, Bryan NS.

Dietary nitrite prevents hypercholesterolemic microvascular inflammation and reverses endothelial dysfunction.

Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1281-8. Epub 2009 Feb 27.

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Stokes KY, Calahan L, Hamric CM, Russell JM, Granger DN.

CD40/CD40L contributes to hypercholesterolemia-induced microvascular inflammation.

Am J Physiol Heart Circ Physiol. 2009 Mar;296(3):H689-97. Epub 2008 Dec 26.

abstractpdf-file
 

Singer G, Stokes KY, Terao S, Granger DN.

SEPSIS-INDUCED INTESTINAL MICROVASCULAR AND INFLAMMATORY RESPONSES IN OBESE MICE.
Shock. 2008 Jul 24. [Epub ahead of print]

abstractpdf-file

 

Tomas Welbourne  

Steffan JJ, Williams BC, Welbourne T, Cardelli JA.
HGF-induced invasion by prostate tumor cells requires anterograde lysosome trafficking and activity of Na+-H+ exchangers.
J Cell Sci. 2010 Apr 1;123(Pt 7):1151-9. Epub 2010 Mar 9.

pdf-fileabstract
   

Steffan JJ, Snider JL, Skalli O, Welbourne T, Cardelli JA.

Na/H Exchangers and RhoA Regulate Acidic Extracellular pH-Induced Lysosome Trafficking in Prostate Cancer Cells.

Traffic. 2009 Mar 17. [Epub ahead of print]

abstract
   

Oliver R 3rd, Friday E, Turturro F, Welbourne T.

Troglitazone induced cytosolic acidification via extracellular signal-response kinase activation and mitochondrial depolarization: complex I proton pumping regulates ammoniagenesis in proximal tubule-like LLC-PK1 cells.

Cell Physiol Biochem. 2008;22(5-6):475-86. Epub 2008 Dec 9.

abstract

 

 


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