LSUHSC -- Department of Molecular and Cellular Physiology

Yijun Jin, Ph.D.

Assistant Professor
Ph.D., 2001, Indiana University School of Medicine

Department of Molecular and Cellular Physiology
LSU Health Sciences Center
1501 Kings Highway
Shreveport, LA 71130
Phone: 318-675-6974
Fax: 318-675-6005
E-mail: yjin@lsuhsc.edu


Regulation of cellular signal transduction by receptor trafficking Tumor necrosis factor (TNF), upon binding its receptor on cell surface, leads to a host of diverse cellular response, including inflammation, proliferation and apoptosis. TNF signal transduction can be regulated by cytoskeleton dynamics. Trafficking of TNF receptor-1 between the plasma membrane and intracellular compartments such as Golgi apparatus is facilitated by myosin II, a motor protein that interacts with actin cytoskeleton. We are currently studying how cell surface TNF receptor dynamics impacts intracellular TNF signaling and the resulting cellular responses. We are also focusing on the molecular mechanisms underlying the association of myosin II motor and TNF receptor. Using genomic and proteomic approaches, more proteins are being identified as the cargoes moved by myosin II, expanding the important roles myosin II and the actin cytoskeleton play in regulating signal transduction and cellular functions. In resting cells, TNF receptor-1 is mostly intracellular (left). Upon stimulation, TNFR1 disperses to the plasma membrane (middle), the process of which is inhibited by ablation of myosin II motor activity (right).
Publications

For a complete list of publications by Yijun Jin in PubMed click here: